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発表論文

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2018

Murata S., Takahama Y., Kasahara M. and Tanaka K. The immunoproteasome and thymoproteasome: functions, evolution and human disease. Nat. Immunol. 19, 923-931 (2018).
Park, J.K., Otsuka, N. Tomaru U., Suzuki H., Azuma M., Okamoto K., Yamashiro K. and Kasahara M. Hum. Pathol. 80:104-112 (2018).
Miyatake Y., Ohta Y., Ikeshita S. and Kasahara M. Anchorage-dependent multicellular aggregate formation induces a quiescent stem-like intractable phenotype in pancreatic cancer cells. Oncotarget 9, 29845-29856 (2018).
Miyatake Y., Kuribayashi-Shigetomi K., Ohta Y., Ikeshita S., Subagyo A., Sueoka K., Kakugo A., Amano M., Takahashi T., Okajima T. and Kasahara M. Visualising the dynamics of live pancreatic microtumours self-organised through cell-in-cell invasion. Sci Rep. 8, 14054, doi: 10.1038/s41598-018-32122-w (2018).
 

2017

Kiuchi, S., Tomaru, U., Ishizu, A., Imagawa, M., Kiuchi, T., Iwasaki, S., Suzuki, A., Otsuka, N., Deguchi, T., Shimizu, T., Marukawa, K., Matsuno, Y. and Kasahara, M. Expression of cathepsins V and S in thymic epithelial tumors.  Hum. Pathol. 60, 66-74 (2017).
Yoshida, S., Shime, H., Funami, K., Takaki, H., Tomiyama, T., Matsumoto, M., Kasahara, M. and Seya, T. The anti-oxidant ergothioneine augments the immunomodulatory function of TLR agonists by direct action on macrophages. PLoS ONE 12, e0169360 (2017).
Ohigashi, I., Ohte, Y., Setoh, K., Nakase, H., Maekawa, A., Kiyonari, H., Hamazaki, Y., Sawawa, H., Omae, Y., Mizokami, M., Tanaka, Y., Yuliwulandari, R., Inoue, H., Kasahara M., Tokunaga, K., Tanaka, K, Matsuda, F., Murata, S. and Takahama, Y. A human PSMB11 polymorphism affects molecular processing of thymoproteasome and thymic production of CD8+ T cells. JCI Insight 2,  doi: 10.1172/jci.insight.93664 (2017).
 

2016

Sutoh, Y. and Kasahara, M. The immune system of agnathans (jawless vertebrates). In: Ratcliffe, M. J. H. (ed.): Encyclopedia of Immunobiology, Vol. 1, Academic Press, Oxford, UK, pp. 468-473 (2016).
Sutoh, Y. and Kasahara, M. Lymphocyte populations in jawless vertebrates: insights into the origin and evolution of adaptive immunity. In: Malagoli, D. (ed.): “The Evolution of the Immune System: Conservation and diversification”, pp. 51-67, Academic Press, Amsterdam (2016).
Kasamatsu, J., Deng, M., Matsumoto, M., Azuma, M., Funami, K., Shime, H., Kasahara, M., Oshiumi, H. and Seya, T. Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.  BMC Immunol. 17: 9, DOI 10.1186/s12865-016-0147-y (2016).
 

2015

Ikeshita, S., Kiuchi, S., Miyatake, Y. and Kasahara, M. Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis. Mol. Exp. Pathol. 98, 41-46 (2015).
Miyatake, Y., Sheefy, N., Ikeshita, S., Hall, W. W. and Kasahara, M. Anchorage-dependent  multicellular aggregate formation induces CD44 high cancer stem cell-like ATL cells in an NF-κB- and vimentin-dependent manner. Cancer Lett. 357, 355-363 (2015). 
Iinuma, C., Waki, M., Kawakami, A., Yamaguchi, M., Tomaru, U., Sasaki, N., Masuda, S.,  Mtasui, Y., Iwasaki, S., Baba, T., Kasahara, M., Yoshiki, T. Paletta, D,, Herrmann, T. and Ishizu, A. Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis.  Int. Immunol. 27, 105-114 (2015).
Fujita, H., Hatanaka, Y., Sutoh, Y., Suzuki, Y., Oba, K., Kubota, K. C., Otsuka, N., Fugo, K., Mitsuhashi, T., Kasahara, M. and Matsuno, Y. Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms. J. Histochem. Cytochem. 63, 217-227 (2015).
Miyatake, Y. and Kasahara, M. Anchorage-dependent multicellular aggregate formation induces CD44 high cancer stem cell-like phenotypes in adult T cell leukemia/lymphoma cells. In: Seya, T., Matsumoto, M., Udaka, K. and Sato, N. (eds.): “Inflammation and Immunity in Cancer”, pp. 75-84, Springer, Tokyo, (2015).
Mohamed, R. H., Sutoh, Y., Itoh, Y., Miyatake, Y., Otsuka, N., Ogasawara, K. and Kasahara, M. The SKINT1-like gene is inactivated in hominoids but not in all primate species: implications for the origin of epidermal dendritic T cells. PLoS ONE 10, e0123258 (2015).
Tsuchisaka, A., Kaneko, S., Imaoka, K., Ota, M., Kishimoto, K., Tomaru, U., Kasahara, M., Ohata, C., Furumura, M., Takamori, S., Morita, E. and Hashimoto, T. Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. Br. J. Dermatol. 173, 268-271 (2015).
Tomaru, U., Tsuji, T., Kiuchi, S., Ishizu, A., Otsuka, N., Ito, T., Ikeda, H., Fukasawa, Y. and Kasahara, M. Decreased expression of a thymus-specific proteasome subunit β5t in Down syndrome patients.  Histopathology 67, 235-244 (2015).
Yamada, Y., Tomaru, U., Ishizu, A., Ito, T., Kiuchi, T., Ono, A., Miyajima, S., Nagai, K., Higashi, T., Matsuno, Y., Dosaka-Akita, H., Nishimura, M., Miwa, S. and Kasahara, M. Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema. Lab. Invest. 95, 625-634 (2015).
Sutoh, Y. and Kasahara, M. The immune system of agnathans (jawless vertebrates). In: Ratcliffe, M. J. H. (ed.): Encyclopedia of Immunobiology, Elsevier, UK (2015).
Kasahara, M. Variable lymphocyte receptors: a current overview. In: Hsu, E. and Du Pasquier, L. (eds.): Pathogen-Host Interactions: Antigenic Variation versus Somatic Adaptations, Volume 57 of the series Results and Problems in Cell Differentiation, pp. 175-192, Springer, New York (2015).
Kasahara, M. and Sutoh, Y. Comparative genomics of the NKG2D ligand gene family. Immunol. Rev. 267, 72-87 (2015).
Kasahara, M. The next top models. Ancient immunity. Cell 163, 19 (2015).
 

2014

Venkatesh, B., Lee, A. P., Ravi, V., Maurya, A. K., Lian, M. M., Swann, J. B., Ohta, Y., Flajnik, M. F., Sutoh, Y., Kasahara, M., Hoon, S., Gangu, V., Roy, S. W., Irimia, M., Korzh, V., Kondrychyn, I., Lim, Z. W., Tay, B.-H., Tohari, S., Kong, K. W., Ho, S., Lorente-Galdos, B., Quilez, J., Marques-Bonet, T., Raney, B. J., Ingham, P. W., Tay, A., Hillier, L. W., Minx, P., Boehm, T., Wilson, R. K., Brenner, S. and Warren, W. C. The elephant shark genome provides unique insights into gnathostome evolution. Nature 505, 174-179 (2014).
Ibusuki, A., Kawai, K., Yoshida, S., Uchida, Y., Nitahara-Takeuchi, A., Kuroki, K., Kajikawa, M., Ose, T., Maenaka, K., Kasahara, M. and Kanekura, T. NKG2D triggers cytotoxicity in murine epidermal gd T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway. J. Invest. Dermatol. 134396-404 (2014).
Ströbel, P., Hartmann, E., Rosenwald, A., Kalla, J., Ott, G., Schalke, B., Kasahara, M., Tomaru, U. and Marx, A. Corticomedullary differentiation and maturational arrest in thymomas.  Histopathology 64557-566 (2014).
Kanda, R., Sutoh, Y., Kasamatsu, J., Maenaka, K., Kasahara, M. and Ose, T. Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module. PLoS ONE 9e85875 (2014).
Kasahara, M. and Sutoh, Y. Two forms of adaptive immunity in vertebrates: similarities and differences.  Adv. Immunol. 12259-90 (2014).
Yamada, Y., Tomaru, U., Ishizu, A., Kiuchi, T., Kasahara, M. and Matsuno, Y. Expression of thymoproteasome subunit β5t in type AB thymoma. J. Clin. Pathol. 67, 276-278 (2014).
Sutoh, Y. and Kasahara, M. Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by T-cell-like and B-cell-like lymphocytes. Immunogenetics 66, 403-409 (2014).
Ikeshita, S., Miyatake, Y., Otsuka, N. and Kasahara, M. MICA/B expression in macrophage foam cells infiltrating atheromatous plaques. Exp. Mol. Pathol. 97171-175 (2014).
Venkatesh, B., Lee, A. P., Swann, J. B., Ohta, Y., Flajnik, M. F., Kasahara, M., Boehm, T. and Warren, W. C. Brief communication arising: Venkatesh et al. reply. Nature 511, E9–E10 (2014).
Ando, R., Noda, K., Tomaru, U., Kamoshita, M., Ozawa, Y., Notomi, S., Hisatomi, T., Noda, M., Kanda, A., Ishibashi, T., Kasahara, M. and Ishida, S. Decreased proteasomal activity causes photoreceptor degeneration in mice.  Invest. Ophthalmol. Vis. Sci. 55, 4682-4690 (2014).
Sato, T., Yamano, Y., Tomaru, U., Shimizu, Y., Ando, H., Okazaki, T., Nagafuchi, H., Shimizu, J., Ozaki, S., Miyazawa, T., Yudoh, K., Oka, H. and Suzuki, N. Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. Mod. Rheumatol. 24, 129-136 (2014).
Araya, N., Sato, T., Ando, H., Tomaru, U., Yoshida, M., Coler-Reilly, A., Yagishita, N., Yamauchi, J., Hasegawa, A., Kannagi, M., Hasegawa, Y., Takahashi, K., Kunitomo, Y., Tanaka, Y., Nakajima, T., Nishioka, K., Utsunomiya, A., Jacobson, S. and Yamano, Y. HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. J. Clin. Invest. 124, 3431-3442 (2014).
Hamano, R., Baba, T., Sasaki, S., Tomaru, U., Ishizu, A., Kawano, M., Yamagishi, M. and Mukaida, N. Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses. Eur. J. Immunol. 44, 1005-1015 (2014).
Nakazawa, D., Shida, H., Tomaru, U., Yoshida, M., Nishio, S., Atsumi, T. and Ishizu, A. Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis. J. Am. Soc. Nephrol. 25, 990-997 (2014).
 

2013

Kasahara, M. Polyploid origin of the human genome. (3rd Ed.). In: eLS. John Wiley & Sons Ltd, Chichester, UK. DOI: 10.1002/9780470015902.a0005071.pub3 (January 15, 2013).
Fukaya, S., Matsui, Y., Tomaru, U., Kawakami, A., Sogo, S., Bohgaki, T., Atsumi, T., Koike, T., Kasahara, M. and Ishizu, A. Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. Lab. Invest. 9372-80 (2013).
Miyatake, Y., Oliveira, A. L. A., Jarboui, M. A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M. Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells.  Am. J. Pathol. 182, 1832-1842 (2013).
Tomaru, U. and Kasahara, M. Thymoproteasome: roles in thymic selection and clinical applications as a diagnostic marker of thymic epithelial tumors.  Arch. Immunol. Ther. Exp. 61, 357-365 (2013).
Kasahara, M. Déjà vu: three lineages of lymphocytes in lampreys. Immunol. Cell. Biol. 91, 599-600 (2013).
Kasahara, M. Impact of whole-genome duplication on vertebrate development and evolution.  Semin. Cell Dev. Biol. 24, 81-82 (2013).
 

2012

Sutoh, Y., Kondo, M., Ohta, Y., Ota, T., Tomaru, U., Flajnik, M. F. and Kasahara, M. Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes. Immunogenetics 64, 49-58 (2012).
Boehm, T., McCurley, N., Sutoh, Y., Schorpp, M., Kasahara, M. and Cooper, M. D. VLR-based adaptive immunity. Annu. Rev. Immunol. 30, 203-220 (2012).
Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., Tanaka, K. and Kasahara, M. Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am. J. Pathol. 180, 963-972 (2012).
Yoshida, S., Mohamed, R. H., Kajikawa, M., Koizumi, J., Tanaka, M., Fugo, K., Otsuka, N., Maenaka, K., Yagita, H., Chiba, H. and Kasahara, M. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J. Immunol. 188, 3972-3979 (2012).
Hoffman, G. E., Le, W. W., Entezam, A., Otsuka, N., Tong, Z. B., Nelson, L. M., Flaws, J. A., McDonald, J. H., Jafar, S. and Usdin, K. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. J. Histochem. Cytochem. 60, 439-456 (2012).
Tomaru, U., Yamada, Y., Ishizu, A., Kuroda, T., Matsuno, Y. and Kasahara, M. Proteasome subunit β5t expression in cervical ectopic thymoma. J. Clin. Pathol. 65, 858-859 (2012).
Kasahara, M. and Yoshida, S. Immunogenetics of the NKG2D ligand gene family. Immunogenetics 64, 855-867 (2012).
Baba, T., Badr, Mel S., Tomaru, U., Ishizu, A. and Mukaida, N. Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model. PLoS ONE 7, e41154 (2012).
Ng, S. Y. L., Chow, B. K. C., Kasamatsu, J., Kasahara, M. and Lee, L. T. O. Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms. PLoS ONE 7, e44691 (2012).
Nakazawa, D., Tomaru, U., Suzuki, A., Hasegawa, R., Kobayashi, T., Nishio, S., Kasahara, M. and Ishizu, A. Abnormal conformation and impaired degradation of NETs induced by propylthiouracil: Implication of disordered NETs in MPO-ANCA-associated vasculitis. Arthritis Rheum. 64, 3779-3787 (2012).
Sato, T., Tsujino, I., Ohira, H., Oyama-Manabe, N., Yamada, Y., Otsuka, N. and Nishimura, M. Right atrial late gadolinium enhancement on cardiac magnetic resonance imaging in pulmonary hypertension. Circ. J. 76, 238-239 (2012).
Katsurada, T., Kobayashi, W., Tomaru, U., Baba, T., Furukawa, S., Ishizu, A., Takeda, K., Sakamoto, N., Asaka, M., Takeda, H. and Kasahara, M. Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis. PLoS ONE 7, e44113 (2012).
 

2011

Shinohara, N., Takahashi, M., Kamishima, T., Ikushima, H., Otsuka, N., Ishizu, A., Shimizu, C., Kanayama, H. and Nonomura, K. The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma. Brit. J. Cancer 104, 241-247 (2011).
Iwasaki, S., Masuda, S., Baba, T., Tomaru, U., Katsumata, K., Kasahara, M. and Ishizu, A. Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes. Cytometry A. 79, 46-56 (2011).
Furuya, M., Nagahama, K., Ishizu, A., Otsuka, N., Nagashima, Y. and Aoki, I. Complexity of tumor vasculature and molecular targeting therapies. Front. Biosci. (Elite Ed) 3, 549-561 (2011).
Otsuka, N., Tong, Z. B., Vanevski, K., Tu, W., Cheng, M. H. and Nelson, L. M. Autoimmune oophoritis with multiple molecular targets mitigated by transgenic expression of Mater. Endocrinology 152, 2465-2473 (2011).
Watari, H., Michimata, R., Yasuda, M., Ishizu, A., Tomaru, U., Xiong, Y., Hassan, M. K. and Sakuragi, N. High prevalence of multiple human papillomavirus infection in Japanese patients with invasive uterine cervical cancer. Pathobiology 78, 220-226 (2011).
Yamada, Y., Tomaru, U., Ishizu, A., Kiuchi, T., Marukawa, K., Matsuno, Y. and Kasahara, M. Expression of proteasome subunit β5t in thymic epithelial tumors. Am J Surg Pathol. 35, 1296-1304 (2011).
Kasahara, M. Immune system: evolutionary pressure of infectious agents. In: D. N. Cooper and H. Kehrer-Sawatzki (eds.): Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, http://www.els.net/ [DOI: 10.1002/9780470015902.a0001131.pub2], UK (2011).
 

2010

Kasahara, M. Genome duplication and T cell immunity. In: Liston, A. (ed.): “Development of T Cell Immunity”, Progress in Molecular Biology and Translational Science 92, 7-36, Elsevier, B.V. (2010).
Kasamatsu, J., Oshiumi, H., Matsumoto, M., Kasahara, M. and Seya, T. Phylogenetic and expression analysis of lamprey Toll-like receptors. Dev. Comp. Immunol. 34, 855-865 (2010).
Flajnik, M. F. and Kasahara, M. Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat. Rev. Genet. 11, 47-59 (2010).
Tatsumi, K., Sou, Y. S., Tada,  N., Nakamura, E., Iemura, S., Natsume, T., Kang, S. H., Chung, C. H., Kasahara, M., Kominami, E., Yamamoto, M., Tanaka, K. and Komatsu, M. A novel type of E3-ligase for the Ufm1-conjugation system. J. Biol. Chem. 285, 5417-5427 (2010).
Ishizu, A., Abe, A., Miyatake, Y., Baba, T., Iinuma, C., Tomaru, U. and Yoshiki, T. Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells. Mod. Rheumatol. 20, 134-138 (2010).
Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N. and Kasahara, M. Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution. Immunogenetics 62, 441-450 (2010).
Yamada, T., Yamada, T., Yamamura, M. K., Katabami, K., Hayakawa, M., Tomaru, U., Shimada, S., Morikawa, M., Seki, T., Ariga, S., Ishikawa, K., Ikebe, T., Gando, S. and Minakami, H. Invasive group A streptococcal infection in pregnancy. J. Infect. 60, 417-424 (2010).
Koiwa, H., Tsujino, I., Ohira, H., Yoshinaga, K., Otsuka, N. and Nishimura, M. Images in cardiovascular medicine: Imaging of cardiac sarcoid lesions using fasting cardiac 18F-fluorodeoxyglucose positron emission tomography: an autopsy case. Circulation 122, 535-536 (2010).
Kasamatsu, J., Sutoh, Y., Fugo, K., Otsuka, N., Iwabuchi, K. and Kasahara, M. Identification of a third variable lymphocyte receptor in the lamprey. Proc. Natl. Acad. Sci. USA 107, 14304-14308 (2010).
 

2009

Tomaru, U., Ishizu, A., Murata, S., Miyatake, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K. and Kasahara, M. Exclusive expression of proteasome subunit β5t in the human thymic cortex. Blood 113, 5186-5191 (2009).
Suzuki, M., Shinagawa, N., Oizumi, S., Fugo, K. and Nishimura, M. Interleukin-6-producing undifferentiated thymic carcinoma with neuroendocrine features. Lung Cancer 63, 425-429 (2009).
Sasaki, N., Ogawa, Y., Tomaru, U., Katsumata, K., Tanaka, S., Otsuka, N., Kasahara, M., Yoshiki, T. and Ishizu, A. Human endogenous retrovirus-R env glycoprotein as autoantigen in autoimmune disease. AIDS Res. Hum. Retroviruses 25, 889-896 (2009).
 

2008

Tajima, M., Wakita, D., Noguchi, D., Chamoto, K., Yue, Z., Fugo, K., Ishigame, H., Iwakura, Y., Kitamura, H., and Nishimura, T. IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J. Exp. Med. 205, 1019-1027 (2008).
Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama T., Hayashi, H., Kishimoto, T., Niwa, S., Kasahara, M., Kurimoto, E., Sakata, E., Takagi, K., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T. and Tanaka, K. Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat. Struct. Mol. Biol. 15, 228-236 (2008).
Baba, T., Iwasaki, S., Maruoka, T., Suzuki, A., Tomaru, U., Ikeda, H., Yoshiki, T., Kasahara, M. and Ishizu, A. Rat CD4+/CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. J. Immunol. 180, 2999-3006 (2008).
Takada, A., Yoshida, S., Kajikawa, M., Miyatake, Y., Tomaru, U., Sakai, M., Chiba, H., Maenaka, K., Kohda, D., Fugo, K. and Kasahara, M. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol. 180, 1678-1685 (2008).
Kasahara, M., Kasamatsu, J. and Sutoh, Y. Two types of antigen receptor systems in vertebrates. Zoolog. Sci. 25, 969-975 (2008).
Kasahara, M. Polyploid origin of the human genome. In: D. N. Cooper and H. Kehrer-Sawatzki (eds.): Handbook of Human Molecular Evolution, John Wiley & Sons, New York (2008).
Holland, L. Z., Albalat, R., Azumi, K., Benito-Gutiérrez, E., Blow, M. J., Bronner-Fraser, M., Brunet, F., Butts, T., Candiani, S., Dishaw, L. J., Ferrier, D. E. K., Garcia-Fernàndez, J., Gibson-Brown, J. J, Gissi, C., Godzik, A., Hallbröök, F., Hirose, D., Hosomichi, K., Ikuta, T., Inoko, H., Kasahara, M., Kasamatsu, J., Kawashima, T., Kimura, A., Kobayashi, M., Kozmik, Z., Kubokawa, K., Laudet, V., Litman, G. W., McHardy, A. C., Meulemans, D., Nonaka, M., Olinski, R. P., Pancer, Z., Pennacchio, L. A., Pestarino, M., Rast, J. P., Rigoutsos, I., Robinson-Rechavi , M., Roch, G., Saiga, H., Sasakura, Y., Satake, M., Satou, Y., Schubert, M., Sherwood, N., Shiina, T., Takatori, N., Tello, J., Vopalensky, P., Wada, S., Xu, A., Ye, Y., Yoshida, K., Yoshizaki, F., Yu, Jr-K., Zhang, Q., Zmasek, C. M., Putnam, N. H., Rokhsar, D. S., Satoh, N. and Holland, P. W. H. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res. 18, 1100-1111 (2008).
Tanabe, Y., Yasuda, K., Azuma, C., Taniguro, H., Onodera, S., Suzuki, A., Chen, Y. M., Gong, J. P. and Osada, Y. Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues. J. Mater. Sci. Mater. Med. 19, 1379-1387 (2008).
 

2007

Kasahara, M. Polyploid origin of the human genome. In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester, http://www.els.net/ [DOI: 10.1002/9780470015902.a0005071.pub2] (2007).
Kasahara, M. The 2R hypothesis: An update. Curr. Opin. Immunol. 19, 547-552 (2007).
Furlong, R. F., Younger, R., Kasahara, M., Reinhardt, R., Thorndyke, M. and Holland, P. W. H. A degenerate ParaHox gene cluster in a degenerate vertebrate. Mol. Biol. Evol. 24, 2681-2686 (2007).
Chen, J., Zhao, X., Lai, Y., Suzuki, A., Tomaru, U., Ishizu, A., Takada, A., Ikeda, H., Kasahara, M. and Yoshiki, T. Enhanced production of p24 Gag protein in HIV-1-infected rat cells fused with uninfected human cells. Exp. Mol. Pathol. 83, 125-130 (2007).
Kasamatsu, J., Ishijima, J., Matsuda, Y. and Kasahara, M. Two variable lymphocyte receptor genes of the inshore hagfish are located far apart on the same chromosome. Immunogenetics 59, 329-331 (2007).
Busso, D., Goldweic, N. M., Hayashi, M., Kasahara, M. and Cuasnicu, P. S. Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion. Biol. Reprod. 76, 701-708 (2007).
Kim, H. M., Oh, S. C., Lim, K. J., Kasamatsu, J., Heo, J. Y., Lee, H., Yoo, O. J., Kasahara, M. and Li, J.-O. Structural diversity of the hagfish variable lymphocyte receptors. J. Biol. Chem. 282, 6726-6732 (2007).
Takenouchi, N., Jones, K. S., Lisinski, I., Fugo, K., Yao, K., Cushman, S. W., Ruscetti, F. W. and Jacobson, S. GLUT1 is not the primary binding receptor but is associated with cell-cell transmission of HTLV-1. J. Virol. 81, 1506-1510 (2007).
Mol, W., Furukawa, H., Sasaki, S., Tomaru, U., Hayashi, T., Saito, A., Nagao, M., Saito, N., Hata, S. and Yamamoto, Y. Evaluation of the sclerotherapeutic efficacy of ethanol, polidocanol, and OK-432 using an in vitro model. Dermatol. Surg. 33, 1452-1459 (2007).
 

2006

Hirano, Y., Hayashi, H., Iemura, S., Hendil, K. B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K. and Murata, S. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Mol. Cell. 24, 977-984 (2006).
Otsuka, N., Miyatake, Y., Ishizu, A., Tanaka, S., Yamamoto, Y., Ikeda, H. and Yoshiki, T. Expression of human endogenous retrovirus-R gene links to differentiation of squamous cells. AIDS Res. Hum. Retroviruses 22, 1148-1151 (2006).
Jones, K. S., Fugo, K., Petrow-Sadowski, C., Huang, Y., Bertolette, D. C., Lisinski, I., Cushman, S. W., Jacobson, S. and Ruscetti, F. W. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. J. Virol. 80, 8291-8302 (2006).
Kajikawa, M., Baba, T., Tomaru, U., Watanabe, Y., Koganei, S., Tsuji-Kawahara, S., Matsumoto, N., Yamamoto, K., Miyazawa, M., Maenaka, K., Ishizu, A. and Kasahara, M. MHC class I-like MILL molecules are β2-microglobulin-associated, GPI-anchored glycoproteins with unique expression patterns. J. Immunol. 177, 3108-3115 (2006).
Ishizu, A., Ooka, T., Murakami, T. and Yoshiki, T. Rupture of the thyrocervical trunk branch from the subclavian artery in a patient with neurofibromatosis: a case report. Cardiovasc. Pathol. 15, 153-156 (2006).
Grant, C., Oh, U., Fugo, K., Takenouchi, N., Griffith, C. and Yao, K., Newhook, T. E., Ratner, L. and Jacobson, S., Foxp3 represses retroviral transcription bytargeting both NF-kappaB and CREB pathways. PLoS Pathog. 2, e33 (2006).
Miyatake, Y., Ikeda, H., Ishizu, A., Baba, T., Ichihashi, T., Suzuki, S., Tomaru, U., Kasahara, M. and Yoshiki, T. Role of neuronal IFN-gamma in the development of myelopathy in rats infected with human T-cell leukemia virus type 1. Am. J. Pathol. 169, 189-199 (2006).
Haruta, C., Suzuki, T. and Kasahara, M. Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like. Immunogenetics 58, 216-225 (2006).
Fugo, K., Matsuno, Y., Okamoto, K., Kusumoto, M., Maeshima, A., Kaji, M., Takabatake, H., Kondo, H. and Moriyama, N. Solitary capillary hemangioma of the lung: Report of two resected cases detected by high-resolution CT. Am. J. Surg. Pathol. 30, 750-753 (2006).
Oh, U., Grant, C. W., Griffith, C., Fugo, K., Takenouchi, N. and Jacobson, S. Reduced Foxp3 protein expression is associated with inflammatory disease in HTLV-I infection. J. Infect. Dis. 193, 1557-1566 (2006).
Abe, A., Ishizu, A., Fugo, K., Ikeda, H. and Yoshiki, T. Articular tissues expressing the env-pX transgene are required for generation of arthritogenic T cells in human T cell leukemia virus type I transgenic rats. Clin. Exp. Rheumatol. 24, 313-316 (2006).
Baba, T., Ishizu, A., Iwasaki, S., Suzuki, A., Tomaru, U., Ikeda, H., Yoshiki, T. and Kasahara, M. CD4/CD8 double-positive macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype. Blood 107, 2004-2012 (2006).
 

2005

Tomaru, U., Yamano, Y. and Jacobson, S. HTLV-I infection and the nervous system. In: Clinical Neuroimmunology 2nd edition Oxford Medical Publications (2005).
Prat, E., Tomaru, U., Sabater, L., Park, D. M., Granger, R., Kruse, N., Ohayon, J. M., Bettinotti, M. P. and Martin, R. HLA-DRB5*0101 and -DRB1*1501 expression in the multiple sclerosis-associated HLA-DR15 haplotype. J. Neuroimmunol. 167, 108-119 (2005).
Maruoka, T., Tanabe, H., Chiba, M. and Kasahara, M. Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class I-like genes that predates the emergence of mammals. Immunogenetics 57, 590-600 (2005).
Tsuji, T., Ikeda, H., Tsuchikawa, T., Kikuchi, K., Baba, T., Ishizu, A. and Yoshiki, T. Malignant transformation of thymoma in recipient rats by heterotopic thymus transplantation from HTLV-I transgenic rats. Lab. Invest. 85, 851-861 (2005).
Pancer, Z., Saha, N. R., Kasamatsu, J., Suzuki, T., Amemiya, C. T., Kasahara, M. and Cooper, M. D. Variable lymphocyte receptors in hagfish. Proc. Natl. Acad. Sci. USA 102, 9224-9229 (2005).
Hayase, H., Ishizu, A., Ikeda, H., Miyatake, Y., Baba, T., Higuchi, M., Abe, A., Tomaru, U. and Yoshiki, T. Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene. Int. Immunol. 17, 677-684 (2005).
Yamano, Y., Takenouchi, N., Li, H. C., Tomaru, U., Yao, K., Grant, C. W., Maric, D. A. and Jacobson, S. Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. J. Clin. Invest. 115, 1361-1368 (2005).
Furuya, M., Kato, H., Nishimura, N., Ishiwata, I., Ikeda, H., Ito, R., Yoshiki, T. and Ishikura, H. Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets. Cancer Res. 65, 2617-2625 (2005).
Teramoto, K., Tada, M., Tamoto, E., Abe, M., Kawakami, A., Komuro, K., Matsunaga, A., Shindoh, G., Takada, M., Murakawa, K., Kanai, M., Kobayashi, N., Fujiwara, Y., Nishimura, N., Shirata, K., Takahishi, T., Ishizu, A., Ikeda, H., Hamada, J., Kondo, S., Katoh, H., Moriuchi, T. and Yoshiki, T. Prediction of lymphatic invasion/lymph node metastasis, recurrence, and survival in patients with gastric cancer by cDNA array-based expression profiling. J. Surg. Res. 124, 225-236 (2005).
Komuro, K., Tada, M., Tamoto,E., Kawakami, A., Matsunaga, A., Teramoto, K., Shindoh, G., Takada, M., Murakawa, K., Kanai, M., Kobayashi, N., Fujiwara, Y., Nishimura, N., Hamada, J., Ishizu, A., Ikeda, H., Kondo, S., Katoh, H., Moriuchi, T. and Yoshiki, T. Right- and left-sided colorectal cancers display distinct expression profiles and the anatomical stratification allows a high accuracy prediction of lymph node metastasis. J. Surg. Res. 124, 216-24 (2005).
Busso, D., Cohen, D. J., Hayashi, M., Kasahara, M. and Cuasnicu, P. S. Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction. Mol. Hum. Reprod. 11, 299-305 (2005).
Suzuki, T., Shin, I. T., Fujiyama, A., Kohara, Y. and Kasahara, M. Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors. J. Immunol. 174, 2885-2891 (2005).
Baba, T., Ishizu, A., Ikeda, H., Miyatake, Y., Tsuji, T., Suzuki, A., Tomaru, U. and Yoshiki, T. Chronic graft-versus-host disease-like autoimmune disorders spontaneously occurred in rats with neonatal thymus atrophy. Eur. J. Immunol. 35, 1731-1740 (2005).
 

2004

Yamano, Y., Cohen, C. J., Takenouchi, N., Yao, K., Tomaru, U., Li, H. C., Reiter, Y. and Jacobson, S. Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease. J. Exp. Med. 199, 1367-1377 (2004).
Tsuchikawa, T., Ikeda, H., Kikuchi, K., Tsuji T., Baba, T, Ishizu, A., Tanaka, Y., Kato, H. and Yoshiki T. Hematopoietic progenitor cells as possible origins of epithelial thymoma in a human T lymphocyte virus type I pX gene transgenic rat model. Lab. Invest. 84, 245-252 (2004).
Abe, A., Ishizu, A., Ikeda, H., Hayase, H., Tsuji, T., Miyatake, Y., Tsuji, M., Fugo, K., Sugaya, T., Higuchi, M., Matsuno, T. and Yoshiki, T. Bone marrow cells carrying the env-pX transgene play a role in the severity but not prolongation of arthritis in human T-cell leukemia virus type-I transgenic rats: a possible role of articular tissues carrying the transgene in the prolongation of arthritis. Int J. Exp. Pathol. 85, 191-200 (2004).
Miyatake, Y., Ikeda, H., Michimata, R., Koizumi, S., Ishizu, A., Nishimura, N. and Yoshiki, T. Differential modulation of gene expression among rat tissues with warm ischemia. Exp. Mol. Pathol. 77, 222-230 (2004).
Yamamoto, Y., Ishizu, A., Ikeda, H., Otsuka, N. and Yoshiki, T. Dexamethasone increased plasminogen activator inhibitor-1 expression on human umbilical vein endothelial cells: an additive effect to tumor necrosis factor-α. Pathobiology 71, 295-301 (2004).
Takada, M., Tada, M., Tamoto, E., Kawakami, A., Murakawa, K., Shindoh, G., Teramoto, K., Matsunaga, A., Komuro, K., Kanai, M., Fujiwara, Y., Shirata, K., Nishimura, N., Miyamoto, M., Okushiba, S., Kondo, S., Hamada, J., Katoh, H., Yoshiki, T. and Moriuchi, T. Prediction of lymph node metastasis by analysis of gene expression profiles in non-small cell lung cancer. J. Surg. Res. 122, 61-69 (2004).
Murakawa, K., Tada, M., Takada, M., Tamoto, E., Shindoh, G., Teramoto, K., Matsunaga, A., Komuro, K., Kanai, M., Kawakami, A., Fujiwara, Y., Kobayashi, N., Shirata, K., Nishimura, N., Okushiba, S., Kondo, S., Hamada, J., Katoh, H., Yoshiki, T. and Moriuchi, T. Prediction of lymph node metastasis and perineural invasion of biliary tract cancer by selected features from cDNA array data. J. Surg. Res. 122, 184-194 (2004).
Tamoto, E., Tada, M., Murakawa, K., Takada, M., Shindo, G., Teramoto, K., Matsunaga, A., Komuro, K., Kanai, M., Kawakami, A., Fujiwara, Y., Kobayashi N., Shirata, K., Nishimura, N., Okushiba, S., Kondo, S., Hamada, J., Yoshiki, T., Moriuchi, T. and Katoh, H. Gene-expression profile changes correlated with tumor progression and lymph node metastasis in esophageal cancer. Clin. Cancer Res. 10, 3629-3638 (2004).
Kasahara, M., Suzuki, T. and Du Pasquier, L. On the origins of the adaptive immune system: novel insights from protochordates and cold-blooded vertebrates. Trends Immunol. 25, 105-111 (2004).
Takahashi, T., Yawata, M., Raudsepp, T., Lear, T. L., Chowdhary, B. P., Antczak, D. F. and Kasahara, M.  Natural killer cell receptors in the horse: evidence for the existence of multiple transcribed Ly49 genes.  Eur. J. Immunol. 34773-784 (2004).
Maruoka, T., Nagata, T. and Kasahara, M.  Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex.  Immunogenetics 55: 712-716, 2004.
Watanabe, Y., Maruoka, T., Walter, L. and Kasahara, M.  Comparative genomics of the Mill family: a rapidly evolving MHC class I gene family.  Eur. J. Immunol. 34, 1597-1607 (2004).
Suzuki, T., Ota, T., Fujiyama, A. and Kasahara, M.  Construction of a bacterial artificial chromosome library from the inshore hagfish, Eptatretus burgeri: A resource for the analysis of the agnathan genome.  Genes Genet. Syst. 79, 251-253 (2004).
Suzuki, T., Shin-I, T., Kohara, Y. and Kasahara, M.  Transcriptome analysis of hagfish leukocytes: A framework for understanding the immune system of jawless fishes.  Dev. Comp. Immunol. 28, 993-1003 (2004).
 

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