{"id":24,"date":"2021-09-15T11:57:05","date_gmt":"2021-09-15T02:57:05","guid":{"rendered":"https:\/\/dev-path1-med.cambria.ac\/?page_id=24"},"modified":"2022-02-09T16:25:35","modified_gmt":"2022-02-09T07:25:35","slug":"inflammation-cancer","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/inflammation-cancer","title":{"rendered":"\u300c\u708e\u75c7\u3068\u7d44\u7e54\u518d\u751f\u300d\u3068\u300c\u708e\u75c7\u3068\u304c\u3093\u300d\u306e\u7814\u7a76"},"content":{"rendered":"<p>\u300c\u708e\u75c7\u3068\u7d44\u7e54\u518d\u751f\u300d\u3068\u300c\u708e\u75c7\u3068\u304c\u3093\u300d\u306e\u7814\u7a76\u306b\u95a2\u3057\u3066\u306f\u3001\u300c\u708e\u75c7\u8a18\u61b6\u300d\u3068\u300c\u816b\u760d\u60f9\u8d77\u6027\u708e\u75c7\u300d\u3068\u3044\u30462\u3064\u306e\u30ad\u30fc\u30ef\u30fc\u30c9\u3092\u4e2d\u5fc3\u306b\u72ec\u81ea\u306e\u8996\u70b9\u30fb\u5207\u308a\u53e3\u3067\u3001\u708e\u75c7\u306b\u3088\u308b\u7d44\u7e54\u518d\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u306b\u3088\u308b\u3088\u308a\u52b9\u7387\u306e\u3088\u3044\u7d44\u7e54\u518d\u751f\u65b9\u6cd5\u306e\u958b\u767a\u3068\u65b0\u898f\u304c\u3093\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3068\u6cbb\u7642\u65b9\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u308b\u3002\u5b9f\u9a13\u624b\u6cd5\u3068\u3057\u3066\u306f\u3001\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3068\u30b2\u30ce\u30e0\u7de8\u96c6\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u305f<em><i>in vitro<\/i><\/em>\u89e3\u6790\u3084\u72ec\u81ea\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f<em><i>in vivo<\/i><\/em>\u306e\u306a\u3069\u306eWet\u5b9f\u9a13\u3092\u5f97\u610f\u3068\u3057\u3066\u3044\u308b\u304c\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u3084\u7a7a\u9593\u7684\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3001\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u3001\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u306a\u3069\u306e\u7db2\u7f85\u89e3\u6790\u624b\u6cd5\uff08Dry\u89e3\u6790\uff09\u3082\u7a4d\u6975\u7684\u306b\u5c0e\u5165\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306f\u3001\u4e3b\u306b\u809d\u81d3\u3084\u5927\u8178\u306a\u3069\u306e\u6d88\u5316\u5668\u306b\u304a\u3051\u308b\u300c\u708e\u75c7\u3068\u304c\u3093\u300d\u3001\u300c\u708e\u75c7\u3068\u7d44\u7e54\u518d\u751f\u300d\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3092\u4e00\u8cab\u3057\u3066\u884c\u3044\u3001\u591a\u304f\u306e\u7814\u7a76\u539f\u8457\u8ad6\u6587\u3084\u7dcf\u8aac\u3092\u767a\u8868\u3057\u3066\u304d\u305f\uff08<em><i>Nature<\/i><\/em>\u00a02012, <em><i>PNAS<\/i><\/em>\u00a02012, <em><i>Cancer Cell<\/i><\/em>\u00a02014, <em><i>Immunity<\/i><\/em>\u00a02014, <em><i>Cell Metabolism<\/i><\/em>\u00a02014, <em><i>JCI <\/i><\/em>2014, <em><i>PNAS<\/i><\/em>\u00a02014, <em><i>JCI <\/i><\/em>2014, <em><i>Semin Immunol.<\/i><\/em>\u00a02014, <em><i>Nature<\/i><\/em>\u00a02015, <em><i>Cell <\/i><\/em>2015, <em><i>Nature Immunology<\/i><\/em>\u00a02015, <em><i>Genes &amp; Development<\/i><\/em>\u00a02015, <em><i>Cell<\/i><\/em>\u00a02016, <em><i>Nature Communications<\/i><\/em>\u00a02016, <em><i>Cancer Cell<\/i><\/em>, 2016, <em><i>Oncogene<\/i><\/em>\u00a02016, <em><i>FEBS Lett.<\/i><\/em>\u00a02016, <em><i>PNAS <\/i><\/em>2017, <em><i>Nature Reviews Immunology<\/i><\/em>\u00a02018, <em><i>PNAS<\/i><\/em>\u00a02018, <em><i>Cancer Science<\/i><\/em>\u00a02019, <em><i>Nature Metabolism<\/i><\/em>\u00a02020, <em><i>Journal of Hepatology<\/i><\/em>\u00a02020, <em><i>Molecular Cancer Research<\/i><\/em>\u00a02020, <em><i>Int J Mol Sci. <\/i><\/em>2021\u306a\u3069\uff09\u3002\u5927\u8178\u306e\u518d\u751f\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u708e\u75c7\u3068\u7d44\u7e54\u518d\u751f\u3092\u3064\u306a\u3050\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u3057\u3066\u4e16\u754c\u3067\u521d\u3081\u3066Src family kinase (SFK)-YAP\u7d4c\u8def\u306e\u767a\u898b\u3057\u3001\u5927\u8178\u304c\u3093\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u304c\u3093\u7d30\u80de\u81ea\u8eab\u304c\u5f15\u304d\u8d77\u3053\u3059\u816b\u760d\u60f9\u8d77\u6027\u708e\u75c7\u306e\u63d0\u5531\u3057\u3001\u305d\u306e\u91cd\u8981\u6027\u3084\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u591a\u304f\u306e\u5b9f\u9a13\u3092\u901a\u3057\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f(<em><i>Nature<\/i><\/em>\u00a02012, <em><i>Immunity<\/i><\/em>\u00a02014,<em><i>\u00a0Nature<\/i><\/em>\u00a02015, <em><i>Nature Communications<\/i><\/em>\u00a02016, <em><i>PNAS <\/i><\/em>2017, <em><i>Molecular Cancer Research<\/i><\/em>\u00a02020\u306a\u3069)\u00a0\u3002\u809d\u81d3\u304c\u3093\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001 \u72ec\u81ea\u306e\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e\u304b\u3089\u306e\u809d\u7d30\u80de\u304c\u3093\uff08NASH-HCC\uff09\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306e\u6a39\u7acb\u3084\u305d\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066p62\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cd\u8981\u6027\u3084\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u304c\u3069\u306e\u3088\u3046\u306bNASH-HCC\u3092\u4fc3\u9032\u3059\u308b\u304b\u306a\u3069\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f\uff08<em><i>Cancer Cell<\/i><\/em>\u00a02014, <em><i>Cancer Cell<\/i><\/em>\u00a02016, <em><i>Nature Metabolism<\/i><\/em>\u00a02020\u306a\u3069\uff09\u3002\u3055\u3089\u306b\u809d\u81d3\u306b\u304a\u3044\u3066\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u5e79\u7d30\u80de\uff08Hybrid hepatocytes\uff09\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u540c\u5b9a\u3057\u3066\u5831\u544a\u3057\u305f\uff08<em><i>Cell<\/i><\/em>\u00a02015\uff09\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u300c\u708e\u75c7\u3068\u7d44\u7e54\u518d\u751f\u300d\u3068\u300c\u708e\u75c7\u3068\u304c\u3093\u300d\u306e\u7814\u7a76\u306b\u95a2\u3057\u3066\u306f\u3001\u300c\u708e\u75c7\u8a18\u61b6\u300d\u3068\u300c\u816b\u760d\u60f9\u8d77\u6027\u708e\u75c7\u300d\u3068\u3044\u30462\u3064\u306e\u30ad\u30fc\u30ef\u30fc\u30c9\u3092\u4e2d\u5fc3\u306b\u72ec\u81ea\u306e\u8996\u70b9\u30fb\u5207\u308a\u53e3\u3067\u3001\u708e\u75c7\u306b\u3088\u308b\u7d44\u7e54\u518d\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u306b\u3088\u308b\u3088\u308a\u52b9\u7387\u306e\u3088\u3044\u7d44\u7e54\u518d\u751f\u65b9\u6cd5\u306e\u958b\u767a\u3068\u65b0\u898f\u304c\u3093\u5316 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":4,"menu_order":110,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/24"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/comments?post=24"}],"version-history":[{"count":4,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/24\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/24\/revisions\/602"}],"up":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/4"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/media?parent=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}