{"id":34,"date":"2021-09-15T12:31:57","date_gmt":"2021-09-15T03:31:57","guid":{"rendered":"https:\/\/dev-path1-med.cambria.ac\/?page_id=34"},"modified":"2021-10-28T15:19:48","modified_gmt":"2021-10-28T06:19:48","slug":"proteostasis","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/proteostasis.html","title":{"rendered":"\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u7570\u5e38\u3068\u75c5\u614b\u5f62\u6210\u3001\u8001\u5316\u306b\u95a2\u3059\u308b\u7814\u7a76"},"content":{"rendered":"<p>\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6052\u5e38\u6027\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u50cd\u304f\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u304c\u3001\u52a0\u9f62\u306b\u3088\u308b\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u3001\u5bff\u547d\u306b\u5f71\u97ff\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u7b49\u306e\u69d8\u3005\u306a\u8001\u5e74\u671f\u6162\u6027\u75be\u60a3\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u9175\u7d20\u6d3b\u6027\u306e\u4f4e\u3044\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3092\u5168\u8eab\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u6a5f\u80fd\u4f4e\u4e0b\u30de\u30a6\u30b9\u3092\u4f5c\u51fa\u3057\u3001\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u7570\u5e38\u3068\u75c5\u614b\u5f62\u6210\u3001\u8001\u5316\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308a\u5bff\u547d\u306e\u77ed\u7e2e\u3092\u8a8d\u3081\u308b\u3053\u3068\u3001\u8a8d\u77e5\u75c7\u69d8\u306e\u8a18\u540d\u529b\u306e\u4f4e\u4e0b\u7b49\u306e\u5168\u8eab\u6027\u306e\u8001\u5316\u75c5\u614b\u306b\u52a0\u3048\u3001\u74b0\u5883\u56e0\u5b50\u306b\u3088\u308b\u8102\u80aa\u4ee3\u8b1d\u7570\u5e38\u3084\u6162\u6027\u547c\u5438\u5668\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis.png\"><img loading=\"lazy\" class=\"alignnone size-full wp-image-225\" src=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis.png\" alt=\"\" width=\"928\" height=\"420\" srcset=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis.png 928w, https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis-640x290.png 640w, https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis-320x145.png 320w, https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-content\/uploads\/2021\/10\/proteostasis-480x217.png 480w\" sizes=\"(max-width: 928px) 100vw, 928px\" \/><\/a><\/p>\n<h3>\u4e3b\u306a\u8ad6\u6587<\/h3>\n<ul>\n<li>Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M: Decreased proteasomal function induces neuronal loss and memory impairment. Am J Pathol 191(1):144-156, 2019.<\/li>\n<li>Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M: Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. Lab Invest 95(6):625-634, 2015.<\/li>\n<li>Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M: Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am J Pathol 180(3):963-972, 2012.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6052\u5e38\u6027\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u50cd\u304f\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u304c\u3001\u52a0\u9f62\u306b\u3088\u308b\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u3001\u5bff\u547d\u306b\u5f71\u97ff\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u7b49\u306e\u69d8\u3005\u306a\u8001\u5e74\u671f\u6162\u6027\u75be\u60a3\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u95a2\u9023\u3059\u308b [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":87,"menu_order":130,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/34"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/comments?post=34"}],"version-history":[{"count":4,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":384,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/34\/revisions\/384"}],"up":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/pages\/87"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/path1.med\/Root\/wp-json\/wp\/v2\/media?parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}